Ribosomal Protein S15 Leader clan

The Ribosomal Protein S15 Leader clan includes RF00114, RF03137, RF03143 and RF0 families, they are RNA motifs used as an autoregulatory mechanism to control the concentration of the ribosomal protein S15 [1,2]. S15 rleaders have been reported in bacteria and in archaea [2]

This clan contains 4 families and the total number of sequence regions in the clan is 1,240.

Literature references

1. Benard L, Philippe C, Ehresmann B, Ehresmann C, Portier C, Biochimie 1996;78:568-576.: Pseudoknot and translational control in the expression of the S15 ribosomal protein. 8955900
2. Eckert I, Weinberg Z, BMC Microbiol. 2020;20:130.: Discovery of 20 novel ribosomal leader candidates in bacteria and archaea. 32448158

Members

This clan contains the following 4 member families:

S15 S15-Methanomicrobia S15-Halobacteria S15-Flavobacteria

For those sequences which have a structure in the Protein DataBank, we generate a mapping between EMBL, PDB and Rfam coordinate systems. The table below shows the mapping between the Rfam families in this clan, the corresponding EMBL entries, and the region of the three-dimensional structures that are available for that sequence.

This tool allows you to view the secondary structure images of two clan members side-by-side. Choose the family structures using the two drop-down menus below.

The table below shows the number of occurrences of each family throughout the sequence database. In brackets beside each number is the percentage of the total number of sequence hits for the clan that are represented by this family. The rightmost column provides a link to the alignments tab for each family.

Rfam family	Num. regions	Alignment
S15-Flavobacteria (RF03161)	381 (30.7%)	View
S15-Halobacteria (RF03143)	118 (9.5%)	View
S15-Methanomicrobia (RF03137)	14 (1.1%)	View
S15 (RF00114)	727 (58.6%)	View